Institution is known for its Research ambiance with the State-of-the-Art Research Facilities and Biotechnology Research is the institution's strong USP.

The college offers Biotechnology Programme from Undergraduate to Doctoral Levels and the college has established "Centre of Excellence in Biotechnology' harnessing Industry-Agriculture-Academic Synergies.

The college has been granted the coveted. Status of 'College with Potential for Excellence' by the UGC and Vaze – Kelkar College is the only college in Mumbai University to get this prestigious award in the first list of colleges in India The Project involves Plant Tissue Culture, Animal Tissue Culture, Chemical Analysis, Molecular Analysis and Digital Data Documentation

College also has Centre for Advanced Research in Natural and Synthetic Chemistry dedicated to synthesis of basic Cosmetic and Perfumery materials